Introduction to Clinical Epidemiology and Clinical Research

MED 483

September 25 -  28 and October 2 - 5, 2006

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• Recommended Text
• List of Participants MED-483
• Course Schedule MED 483
• Overview- Dr. Thomas Casale
• Research Design- Dr. Robert Heaney 
• Clinical Trial Design- Dr. Robert Heaney
• Randomization Strategies and Issues- Dr. Robert Heaney
• Issues in Measurement- Reliability and Validity- Dr. Lee Morrow
• Intro to Retrospective/Prospective Clinical Research Designs- Dr. Lee Morrow
• Introduction to Statistics and Descriptive Statistics- Dr. JD Bramble
  • Intro to Statistics
  • Statistics cont'
  • Confidence Intervals
• Intro to Writing a Research Article- Dr. Thomas Casale
  • Word-Medex Guide
  • Word-Medex Letter to Submit to a Journal
  • Word-Medex Letter to Resubmit to a Journal
• Intro to Applying for Grant Support- Beth Herr, Karen Malloy and Annie Price
• Peer Review Process- Dr. Lee Morrow
• Survival Analysis- Dr. Lee Morrow
• Evidence Based Medicine and Critical Appraisal of the Literature- Dr. Bruce Houghton
• Strategies to Find and Access Clinical Research Literature Through the Web- Dr. Bruce Houghton
  • Evidenced Based Medicine:  What It is and What It Isn't
  • Does Blood Transfusion Increase the Risk of Infection after Hip Fracture

  • Users' Guides to the Medical Literature XXV. Evidence-Based Medicine:    Principles for Applying the Users' Guides to Patient Care

  • A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
  • Users' Guides Interactive

  • Parachute Use to Prevent Death and Major Trauma Related to Gravitational Challenges:  Systemic Review of Randomized Controlled Trials

  • Laparoscopic versus open appendectomy: prospective randomized trial

  • The Effect of Bisoprolol on Perioperative Mortality and Myocardial Infarction in High-Risk Patients Undergoing Vascular Surgery- (critical appraisal exercise)

  • Are the recommendations to use perioperative ß-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence?

  • A Review of Heart Failure Treatment Gordon H. Guyatt, M.D., M.Sc. ^1,2, and P.J. Devereaux, M.D.

  • Pharmacologic Myocardial Protection in Patients Undergoing Noncardiac Surgery: A Quantitative Systematic Review

• Ethical Issues- Protection of Human Subjects and Ethical Issues in Multimember Trials and Placebo-Controlled Trials Issues Arising from Clinical Research in Vulnerable and Other special Populations -- Dr. John Stone and Dr. Richard O'Brien
  • Nuremberg Code
  • Declaration of Helsinki
  • Tuskegee Study
  • The Belmont Report
  • CIOMS Guidelines
  • Emmanuel et al JAMA 2000
  • Allogeneic Bone Marrow Transplant Case
  • CODE OF FEDERAL REGULATIONS, Title 45, Part 46, Protection of Human Subjects
  • Cardiac Center Gene Study 2006
  • Human Subjects Protection Steinbrook NEJM 2002
  • John Hopkins Asthma Case NEJM 2002
  • Genetics Race and Health BMNJ 2004
  • Race & Drugs. Wood NEJM 2001
  • Racial Profiling. Schwartz. NEJM 2001
• Course  Evaluation